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Nat Methods. 2017 Jun;14(6):587-589. doi: 10.1038/nmeth.4285. Epub 2017 May 8.

ModelFinder: fast model selection for accurate phylogenetic estimates.

Author information

1
Land &Water, CSIRO, Canberra, Australian Capital Territory, Australia.
2
Faculty of Pharmacy &Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada.
3
Center for Integrative Bioinformatics Vienna, Max F. Perutz Laboratories, University of Vienna &Medical University of Vienna, Vienna, Austria.
4
Research School of Biology, Australian National University, Canberra, Australian Capital Territory, Australia.
5
Bioinformatics and Computational Biology, Faculty of Computational Science, University of Vienna, Vienna, Austria.

Abstract

Model-based molecular phylogenetics plays an important role in comparisons of genomic data, and model selection is a key step in all such analyses. We present ModelFinder, a fast model-selection method that greatly improves the accuracy of phylogenetic estimates by incorporating a model of rate heterogeneity across sites not previously considered in this context and by allowing concurrent searches of model space and tree space.

PMID:
28481363
PMCID:
PMC5453245
DOI:
10.1038/nmeth.4285
[Indexed for MEDLINE]
Free PMC Article

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