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J Comput Aided Mol Des. 1987 Jul;1(2):97-119.

Strategic approaches to drug design. II. Modelling studies on phosphodiesterase substrates and inhibitors.

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1
Smith Kline & French Research, The Frythe, Herts, U.K.

Abstract

Modelling studies have been carried out on the phosphodiesterase (PDE) substrates, adenosine- and guanosine-3'5'-cyclic monophosphates, and on a number of non-specific and type III-specific phosphodiesterase inhibitors. These studies have assisted the understanding of PDE substrate differentiation and the design of potent, selective PDE type III inhibitors.

PMID:
2848100
[Indexed for MEDLINE]

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