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Nat Commun. 2017 May 8;8:15150. doi: 10.1038/ncomms15150.

Antibody-powered nucleic acid release using a DNA-based nanomachine.

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Department of Chemistry, University of Rome, Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
Laboratory of Biosensors and Nanomachines, Département de Chimie, Départment de Biochimie et Médecine Moléculaire, Université de Montréal, Montréal, Quèbec, Canada H3T 1J4.


A wide range of molecular devices with nanoscale dimensions have been recently designed to perform a variety of functions in response to specific molecular inputs. Only limited examples, however, utilize antibodies as regulatory inputs. In response to this, here we report the rational design of a modular DNA-based nanomachine that can reversibly load and release a molecular cargo on binding to a specific antibody. We show here that, by using three different antigens (including one relevant to HIV), it is possible to design different DNA nanomachines regulated by their targeting antibody in a rapid, versatile and highly specific manner. The antibody-powered DNA nanomachines we have developed here may thus be useful in applications like controlled drug-release, point-of-care diagnostics and in vivo imaging.

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