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Open Forum Infect Dis. 2017 Jan 30;4(1):ofx002. doi: 10.1093/ofid/ofx002. eCollection 2017 Winter.

Characteristics and Mortality of Pneumocystis Pneumonia in Patients With Cushing's Syndrome: A Plea for Timely Initiation of Chemoprophylaxis.

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Department of Infectious Diseases and.
Department of Medicine, Division of Endocrinology, and Center for Endocrine Tumors, Leiden University Medical Center, The Netherlands.


In patients with Cushing's syndrome, development of Pneumocystis pneumonia (PCP) is associated with extreme cortisol production levels. In this setting, immune reconstitution after abrogation of cortisol excess appears to induce development of symptomatic PCP. The high mortality rate warrants timely initiation of chemoprophylaxis or even preemptive treatment of PCP.


Cushing’s syndrome; PCP; Pneumocystis jirovecii; immune reconstitution; prophylaxis.

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