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Open Forum Infect Dis. 2017 Feb 9;4(1):ofw261. doi: 10.1093/ofid/ofw261. eCollection 2017 Winter.

Disseminated Cryptococcosis With Brain Involvement in Patients With Chronic Lymphoid Malignancies on Ibrutinib.

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Department of Medicine, Duke University, Durham, North Carolina.
Division of Infectious Disease, Washington University, St. Louis, Missouri.
University of Texas MD Anderson Cancer Center, Houston.


We report 2 cases of disseminated cryptococcosis with central nervous system involvement in patients with chronic lymphoid malignancies occurring within 1 month of starting on ibrutinib. Characteristically, in both cases, no inflammation was seen in the cerebrospinal fluid. Central nervous system mycoses should be considered as a potential complication of ibrutinib.


CARD9; central nervous system mycosis; chronic lymphoid malignancies; cryptococcosis; ibrutinib.

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