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Nat Rev Genet. 2017 Jul;18(7):425-440. doi: 10.1038/nrg.2017.19. Epub 2017 May 8.

Comparative transcriptomics in human and mouse.

Author information

1
Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and Technology, Dr. Aiguader 88, 08003 Barcelona, Spain.
2
Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain.
3
Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11742, USA.

Abstract

Cross-species comparisons of genomes, transcriptomes and gene regulation are now feasible at unprecedented resolution and throughput, enabling the comparison of human and mouse biology at the molecular level. Insights have been gained into the degree of conservation between human and mouse at the level of not only gene expression but also epigenetics and inter-individual variation. However, a number of limitations exist, including incomplete transcriptome characterization and difficulties in identifying orthologous phenotypes and cell types, which are beginning to be addressed by emerging technologies. Ultimately, these comparisons will help to identify the conditions under which the mouse is a suitable model of human physiology and disease, and optimize the use of animal models.

PMID:
28479595
DOI:
10.1038/nrg.2017.19
[Indexed for MEDLINE]

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