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Neuroimage. 2017 Aug 1;156:43-64. doi: 10.1016/j.neuroimage.2017.04.035. Epub 2017 May 4.

Freesurfer cortical normative data for adults using Desikan-Killiany-Tourville and ex vivo protocols.

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Centre de recherche CERVO Research Centre, 2601, de la Canardière, Québec, Canada G1J 2G3.
Centre de recherche CERVO Research Centre, 2601, de la Canardière, Québec, Canada G1J 2G3; Département de radiologie, Faculté de médecine, Université Laval, 1050, avenue de la Médecine, Québec, Canada G1V 0A6. Electronic address:


We recently built normative data for FreeSurfer morphometric estimates of cortical regions using its default atlas parcellation (Desikan-Killiany or DK) according to individual and scanner characteristics. We aimed to produced similar normative values for Desikan-Killianny-Tourville (DKT) and ex vivo-based labeling protocols, as well as examine the differences between these three atlases. Surfaces, thicknesses, and volumes of cortical regions were produced using cross-sectional magnetic resonance scans from the same 2713 healthy individuals aged 18-94 years as used in the reported DK norms. Models predicting regional cortical estimates of each hemisphere were produced using age, sex, estimated intracranial volume (eTIV), scanner manufacturer and magnetic field strength (MFS) as predictors. The DKT and DK models generally included the same predictors and produced similar R2. Comparison between DK, DKT, ex vivo atlases normative cortical measures showed that the three protocols generally produced similar normative values.


Aging; Atrophy; Magnetic resonance imaging; Morphometry; Normality; Segmentation; Sex

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