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Dev Biol. 2017 Jul 1;427(1):6-11. doi: 10.1016/j.ydbio.2017.05.001. Epub 2017 May 4.

Pericytes are heterogeneous in their origin within the same tissue.

Author information

1
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
2
Department of Radiology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
3
Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, NC, USA.
4
Department of Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil; Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address: birbrair@icb.ufmg.br.

Abstract

Pericytes heterogeneity is based on their morphology, distribution, and markers. It is well known that pericytes from different organs may have distinct embryonic sources. Yamazaki et al. (2017) using several transgenic mouse model reveal by cell-lineage tracing that pericytes are even more heterogeneous than previously appreciated. This study shows that pericytes from within the same tissue may be heterogeneous in their origin. Remarkably, a subpopulation of embryonic dermal pericytes derives from the hematopoietic lineage, an unexpected source. Reconstructing the lineage of pericytes is central to understanding development, and also for the diagnosis and treatment of diseases in which pericytes play important roles.

KEYWORDS:

Embryonic; Origin; Pericytes; Plasticity; Stem cells

PMID:
28479340
PMCID:
PMC6076854
DOI:
10.1016/j.ydbio.2017.05.001
[Indexed for MEDLINE]
Free PMC Article

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