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Mol Aspects Med. 2017 Dec;58:102-113. doi: 10.1016/j.mam.2017.05.001. Epub 2017 May 11.

Specialized pro-resolving mediators in renal fibrosis.

Author information

1
UCD Diabetes Complications Research Centre, UCD Conway Institute & UCD School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: eoin.brennan@ucd.ie.
2
UCD Diabetes Complications Research Centre, UCD Conway Institute & UCD School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: antonino.cacace@ucd.ie.
3
UCD Diabetes Complications Research Centre, UCD Conway Institute & UCD School of Medicine, University College Dublin, Belfield, Dublin 4, Ireland. Electronic address: catherine.godson@ucd.ie.

Abstract

Inflammation and its timely resolution play a critical role in effective host defence and wound healing. Unresolved inflammatory responses underlie the pathology of many prevalent diseases resulting in tissue fibrosis and eventual organ failure as typified by kidney, lung and liver fibrosis. The role of autocrine and paracrine mediators including cytokines, prostaglandins and leukotrienes in initiating and sustaining inflammation is well established. More recently a physiological role for specialized pro-resolving lipid mediators [SPMs] in modulating inflammatory responses and promoting the resolution of inflammation has been appreciated. As will be discussed in this review, SPMs not only attenuate the development of fibrosis through promoting the resolution of inflammation but may also directly suppress fibrotic responses. These findings suggest novel therapeutic paradigms to treat intractable life-limiting diseases such as renal fibrosis.

KEYWORDS:

Chronic kidney disease; Diabetic kidney disease; Specialized pro-resolving mediators

PMID:
28479307
DOI:
10.1016/j.mam.2017.05.001
[Indexed for MEDLINE]

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