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Lancet. 2017 Jun 10;389(10086):2287-2303. doi: 10.1016/S0140-6736(17)31191-1. Epub 2017 May 4.

Long-term management of moderate-to-severe atopic dermatitis with dupilumab and concomitant topical corticosteroids (LIBERTY AD CHRONOS): a 1-year, randomised, double-blinded, placebo-controlled, phase 3 trial.

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Oregon Medical Research Center, Portland, OR, USA. Electronic address:
University Medical Center Utrecht, Utrecht, Netherlands.
SKiN Centre for Dermatology, Queen's University, and Probity Medical Research, Peterborough, ON, Canada.
Modern Dermatology and Modern Research Associates, and Probity Medical Research, Dallas, TX, USA.
Advanced Medical Research, PC, Atlanta, GA, USA.
Eastern Virginia Medical School and Virginia Clinical Research Inc, Norfolk, VA, USA.
Oregon Health and Science University, Portland, OR, USA.
K Papp Clinical Research and Probity Medical Research, Waterloo, ON, Canada.
Department of Dermatology and Skin Science, University of British Columbia, and Probity Medical Research, Surrey, BC, Canada.
Australian National University, Canberra, and Probity Medical Research, Phillip, ACT, Australia.
The University of Melbourne, Parkville, Skin & Cancer Foundation Inc, Carlton, and Probity Medical Research, Carlton, VIC, Australia.
Erasmus University Medical Center Rotterdam, Rotterdam, Netherlands.
The Dermatology Centre, Salford Royal Hospital, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Tokyo Teishin Postal Services Agency Hospital, Tokyo, Japan.
Department of Dermatology, La Paz University Hospital, Madrid, Spain.
Department of Dermatology, Hospital del Mar, Barcelona, Spain.
Department of Dermatology, Venereology and Allergology, Wroclaw, Poland.
Dermatology and Venereology, Hradec Kralove, Czech Republic.
Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary.
Regeneron Pharmaceuticals Inc, Basking Ridge, NJ, USA.
Regeneron Pharmaceuticals Inc, Tarrytown, NY, USA.
Sanofi, Cambridge, MA, USA.
Sanofi, Chilly-Mazarin, France.
Sanofi, Bridgewater, NJ, USA.



Dupilumab (an anti-interleukin-4-receptor-α monoclonal antibody) blocks signalling of interleukin 4 and interleukin 13, type 2/Th2 cytokines implicated in numerous allergic diseases ranging from asthma to atopic dermatitis. Previous 16-week monotherapy studies showed that dupilumab substantially improved signs and symptoms of moderate-to-severe atopic dermatitis with acceptable safety, validating the crucial role of interleukin 4 and interleukin 13 in atopic dermatitis pathogenesis. We aimed to evaluate the long-term efficacy and safety of dupilumab with medium-potency topical corticosteroids versus placebo with topical corticosteroids in adults with moderate-to-severe atopic dermatitis.


In this 1-year, randomised, double-blinded, placebo-controlled, phase 3 study (LIBERTY AD CHRONOS), adults with moderate-to-severe atopic dermatitis and inadequate response to topical corticosteroids were enrolled at 161 hospitals, clinics, and academic institutions in 14 countries in Europe, Asia-Pacific, and North America. Patients were randomly assigned (3:1:3) to subcutaneous dupilumab 300 mg once weekly (qw), dupilumab 300 mg every 2 weeks (q2w), or placebo via a central interactive voice/web response system, stratified by severity and global region. All three groups were given concomitant topical corticosteroids with or without topical calcineurin inhibitors where inadvisable for topical corticosteroids. Topical corticosteroids could be tapered, stopped, or restarted on the basis of disease activity. Coprimary endpoints were patients (%) achieving Investigator's Global Assessment (IGA) 0/1 and 2-point or higher improvement from baseline, and Eczema Area and Severity Index 75% improvement from baseline (EASI-75) at week 16. Week 16 efficacy and week 52 safety analyses included all randomised patients; week 52 efficacy included patients who completed treatment by US regulatory submission cutoff. This study is registered with, NCT02260986.


Between Oct 3, 2014, and July 31, 2015, 740 patients were enrolled: 319 were randomly assigned to dupilumab qw plus topical corticosteroids, 106 to dupilumab q2w plus topical corticosteroids, and 315 to placebo plus topical corticosteroids. 623 (270, 89, and 264, respectively) were evaluable for week 52 efficacy. At week 16, more patients who received dupilumab plus topical corticosteroids achieved the coprimary endpoints of IGA 0/1 (39% [125 patients] who received dupilumab plus topical corticosteroids qw and 39% [41 patients] who received dupilumab q2w plus topical corticosteroids vs 12% [39 patients] who received placebo plus topical corticosteroids; p<0·0001) and EASI-75 (64% [204] and 69% [73] vs 23% [73]; p<0·0001). Week 52 results were similar. Adverse events were reported in 261 (83%) patients who received dupilumab qw plus topical corticosteroids, 97 (88%) patients who received dupilumab q2w, and 266 (84%) patients who received placebo, and serious adverse events in nine (3%), four (4%), and 16 (5%) patients, respectively. No significant dupilumab-induced laboratory abnormalities were noted. Injection-site reactions and conjunctivitis were more common in patients treated with dupilumab plus topical corticosteroids-treated patients than in patients treated with placebo plus topical corticosteroids.


Dupilumab added to standard topical corticosteroid treatment for 1 year improved atopic dermatitis signs and symptoms, with acceptable safety.


Sanofi and Regeneron Pharmaceuticals Inc.

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