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Trends Mol Med. 2017 Jun;23(6):546-562. doi: 10.1016/j.molmed.2017.04.004. Epub 2017 May 4.

Emerging Role for Methylation in Multiple Sclerosis: Beyond DNA.

Author information

1
School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, Ohio State University, Columbus, OH 43210, USA; Biomedical Sciences Graduate Program, Ohio State University, Columbus, OH 43210, USA.
2
School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, Ohio State University, Columbus, OH 43210, USA; Department of Microbial Infection and Immunity, Ohio State University, Columbus, OH 43210, USA; Department of Neuroscience, Ohio State University, Columbus, OH 43210, USA; Institute of Behavioral Medicine Research, Ohio State University, Columbus, OH 43210, USA. Electronic address: mireia.guerau@osumc.edu.

Abstract

Multiple Sclerosis (MS) is a chronic inflammatory disease of the central nervous system. The inflammatory and neurodegenerative pathways driving MS are modulated by DNA, lysine, and arginine methylation, as evidenced by studies made possible by novel tools for methylation detection or loss of function. We present evidence that MS is associated with genetic variants and metabolic changes that impact on methylation. Further, we comprehensively review current understanding of how methylation can impact on central nervous system (CNS) resilience and neuroregenerative potential, as well as inflammatory versus regulatory T helper (Th) cell balance. These findings are discussed in the context of therapeutic relevance for MS, with broad implications in other neurologic and immune-mediated diseases.

KEYWORDS:

methylation; multiple sclerosis

PMID:
28478950
PMCID:
PMC5492960
DOI:
10.1016/j.molmed.2017.04.004
[Indexed for MEDLINE]
Free PMC Article

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