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J Arthroplasty. 2017 Sep;32(9S):S268-S271. doi: 10.1016/j.arth.2017.03.062. Epub 2017 Apr 6.

Effectiveness of Bupivacaine Liposome Injectable Suspension for Postoperative Pain Control in Total Knee Arthroplasty: A Prospective, Randomized, Double Blind, Controlled Study.

Author information

1
Department of Surgery and Orthopaedic Surgery, DeClaire LaMacchia Orthopaedic Institute, Crittenton Hospital Medical Center, Rochester Hills, Michigan.
2
Wayne State University School of Medicine, Detroit, Michigan.
3
Department of Family Medicine and Public Health Services, Wayne State University School of Medicine Family Medicine Residency Program at Crittenton Hospital, Rochester Hills, Michigan.
4
Department of Biological Sciences, Wayne State University, Detroit, Michigan.

Abstract

BACKGROUND:

We compared the effectiveness of liposomal bupivacaine to ropivacaine, each as part of multimodal pain management, in total knee arthroplasty (TKA) postoperative pain control.

METHODS:

This prospective, double blind study randomized 96 TKA patients into a control group (periarticular injection of ropivacaine, ketorolac, morphine, and epinephrine in saline; 100cc) or an experimental group (periarticular injection of bupivacaine, ketorolac, morphine, and epinephrine in saline; 80cc plus 1.3% liposomal bupivacaine 20cc; total injection 100cc). The postoperative use of narcotics, visual analog pain scores, hours to ambulate 100 feet, and length of hospital stay were recorded.

RESULTS:

There was no significant difference between the two groups (control N = 49, experiment N = 47) in mean narcotic use per hour, total narcotic use during hospital stay, time to ambulate 100 feet, length of hospital stay, or visual analog score for pain postoperatively.

CONCLUSION:

There is no benefit in the use of liposomal bupivacaine compared with ropivacaine for postoperative pain control in TKA.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT02808728.

KEYWORDS:

liposomal bupivacaine; osteoarthritis; pain management; total knee arthroplasty; total knee replacement

PMID:
28478185
DOI:
10.1016/j.arth.2017.03.062
[Indexed for MEDLINE]

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