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Surg Pathol Clin. 2017 Jun;10(2):299-317. doi: 10.1016/j.path.2017.01.005. Epub 2017 Mar 18.

Advances in the Genetic Characterization of Cutaneous Mesenchymal Neoplasms: Implications for Tumor Classification and Novel Diagnostic Markers.

Author information

1
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
2
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA. Electronic address: ladoyle@partners.org.

Abstract

Cutaneous mesenchymal neoplasms often pose significant diagnostic challenges; many such entities are rare or show clinical and histologic overlap with both other mesenchymal and non-mesenchymal lesions. Recent advances in the genetic classification of many cutaneous mesenchymal neoplasms have not only helped define unique pathologic entities and increase our understanding of their biology, but have also provided new diagnostic markers. This review details these recent discoveries, with a focus on their implications for tumor classification and diagnosis.

KEYWORDS:

Immunohistochemistry; Mesenchymal; Neoplasm; Sarcoma; Soft tissue tumor

PMID:
28477882
DOI:
10.1016/j.path.2017.01.005
[Indexed for MEDLINE]

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