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Cell. 2017 May 4;169(4):563-565. doi: 10.1016/j.cell.2017.04.030.

Don't Stop Re-healin'! Cancer as an Ongoing Stem Cell Affair.

Author information

1
Stem Cell Program, Divisions of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
2
Stem Cell Program, Divisions of Hematology/Oncology and Pulmonary and Respiratory Diseases, Children's Hospital Boston, Boston, MA 02115, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: carla.kim@childrens.harvard.edu.

Abstract

Tumors have long been suspected of hijacking stem cell mechanisms used for tissue maintenance and repair. Ge et al. now show that skin tumors exhibit merged chromatin profiles from distinct stem cell lineages. This "lineage infidelity" recreates a state akin to transient wound repair that persists to maintain uncontrolled growth.

PMID:
28475887
DOI:
10.1016/j.cell.2017.04.030
[Indexed for MEDLINE]
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