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Cell Stem Cell. 2017 May 4;20(5):590-592. doi: 10.1016/j.stem.2017.03.025.

Hematopoiesis: Reconciling Historic Controversies about the Niche.

Author information

1
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.
2
Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA; Center for Regenerative Medicine and Cancer Center, Massachusetts General Hospital, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: david_scadden@harvard.edu.

Abstract

The niche, as first conceptualized, was in conflict with the prevailing wisdom that stem cells have internal logic. The niche hypothesis has been indisputably confirmed. Yet, recent findings indicate little plasticity of epigenetically scripted hematopoietic stem/progenitors. Reconciling this conflict requires re-envisioning the niche as an enabler, not designer, of cell fate.

PMID:
28475884
DOI:
10.1016/j.stem.2017.03.025
[Indexed for MEDLINE]
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