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Nutr Neurosci. 2018 Sep;21(7):511-519. doi: 10.1080/1028415X.2017.1317395. Epub 2017 May 5.

The effect of vitamin D supplement on the score and quality of sleep in 20-50 year-old people with sleep disorders compared with control group.

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a Departments of Nutritional Science, Paramedical Faculty , Ahvaz Jundishapur Medical Sciences University , Ahvaz , Iran.
b Department Biostatistics , School of Health, Ahvaz Jundishapur University of Medical Science , Ahvaz , Iran.
c Department of Nutritional Science , Arvand International Division of Ahvaz Jundishapur University of Medical Sciences , Ahvaz , Iran.



Sleep quality may be directly related with vitamin D serum level. Some studies found that people with lower vitamin D serum level experienced a lower sleep quality. Consequently, this study aimed at determining the effect of vitamin D supplements on sleep score and quality in 20-50 year-old people with sleep disorders.


This double blind, clinical trial was performed in November 2015-February 2016 on 89 people with sleep disorders based on Petersburg's Sleep Index. Patient samples were divided randomly into two groups: intervention and placebo. At the end of the study, the data on 89 subjects (44 in intervention group and 45 people in placebo group) were examined. Intervention group received a 50 000-unit vitamin D supplement, one in a fortnight for 8 weeks. Meanwhile, placebo group received placebo. Before and after intervention, Petersburg's Sleep Quality Questionnaire, International Physical Activity Questionnaire, general information questionnaire, sun exposure, vitamin D serum level and 3-day food record questionnaire were assessed and recorded for all participants. To analyze data, t-test, chi square, ANCOVA, U-Mann-Whitney and Wilcoxon statistical tests were used.


Based on the results of the present study, at the end of the study sleep score (PSQI) reduced significantly in vitamin recipients as compared with placebo recipients (P < 0.05). This difference was significant even after modifying confounding variables (P < 0.05).


This study shows that the use of vitamin D supplement improves sleep quality, reduces sleep latency, raises sleep duration and improves subjective sleep quality in people of 20-50 year-old with sleep disorder.


Serum vitamin D; Sleep disorders; Vitamin D supplement

[Indexed for MEDLINE]

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