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CNS Neurol Disord Drug Targets. 2017;16(4):387-397. doi: 10.2174/1871527316666170328113309.

Neuroprotective Effects of Citrus Fruit-Derived Flavonoids, Nobiletin and Tangeretin in Alzheimer's and Parkinson's Disease.

Author information

1
Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney. Australia.
2
School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3
Pharmacognosy Research Laboratories, Medway School of Science, University of Greenwich, Central Avenue, Chatham-Maritime, Kent ME4 4TB, United Kingdom.
4
Attaur- Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad. Pakistan.
5
Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia, Lombardy, Italy.
6
Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
7
Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782. Spain.

Abstract

Neurodegenerative diseases, namely Alzheimer's disease and Parkinson's disease represent a deleterious impact worldwide. Despite extensive preclinical and clinical research in neurodegenerative disorders, therapeutic strategies aimed at the prevention and chronic treatment of neurodegenerative conditions have not been successfully translated to the clinic. Therefore, the identification of novel pharmacological intervention derived from natural products is warranted. Nobiletin and tangeretin are important citrus flavonoids derived from the peel and other parts of Citrus L. genus, and have been shown to exhibit neuroprotective effects in several in vitro and in vivo studies. Apart from there antioxidant and anti-inflammatory effects, nobiletin and tangeretin have been shown to attenuate cholinergic deficits, reduce the abnormal accumulation of neurotoxic amyloid-beta peptides, reverse N-methyl- D-aspartate (NMDA) receptor hypofunction, ameliorate ischemic injury, inhibit hyperphosphorylation of tau protein, enhance neprilysin levels, modulate several signaling cascades, and protect against 1-methyl-4-phenylpyridinium (MPP(+)) and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) toxicity. Taken together, these naturally occurring phytochemicals may represent beneficial drug candidates for the treatment and prevention of Alzheimer's and Parkinson's disease.

KEYWORDS:

Alzheimer's disease; Parkinson’s disease; amyloid; nobiletin; tangeretin; tau

[Indexed for MEDLINE]

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