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J Clin Pharm Ther. 2017 Oct;42(5):624-626. doi: 10.1111/jcpt.12547. Epub 2017 May 5.

Cure with ledipasvir/sofosbuvir for chronic hepatitis C virus in an individual with gastric bypass.

Author information

1
Department of Pharmacy, Novant Health Forsyth Medical Center, Winston-Salem, NC, USA.
2
Department of Pharmacy Practice, Campbell University College of Pharmacy and Health Sciences, Buies Creek, NC, USA.
3
Infectious Diseases Specialist, Novant Health Forsyth Medical Center, Winston-Salem, NC, USA.

Abstract

WHAT IS KNOWN AND OBJECTIVE:

The impact of gastric bypass surgery on the pharmacokinetics of various medications has been reported. Presently, no data exist for the treatment of chronic hepatitis C virus with ledipasvir/sofosbuvir (LDV/SOF) in an individual with a history of gastric bypass.

CASE DESCRIPTION:

We report the successful cure of an individual who was treated with LDV/SOF who had a history of gastric bypass. The patient tolerated LDV/SOF well while only experiencing a minor headache.

WHAT IS NEW AND CONCLUSION:

Ledipasvir/sofosbuvir treatment may still be effective in those with a history of gastric bypass surgery.

KEYWORDS:

LDV/SOF; harvoni; hepatitis C virus; ledipasvir/sofosbuvir

PMID:
28474386
DOI:
10.1111/jcpt.12547
[Indexed for MEDLINE]

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