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Front Neurol. 2017 Apr 20;8:146. doi: 10.3389/fneur.2017.00146. eCollection 2017.

Cerebrovascular Manifestations of Lyme Neuroborreliosis-A Systematic Review of Published Cases.

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Department of Radiology, Medical University of Białystok, Białystok, Poland.
Department of Infectious Diseases and Neuroinfections, Medical University of Białystok, Białystok, Poland.
Department of Neurology, Medical University of Białystok, Białystok, Poland.
Faculty of Applied Informatics and Mathematics, Warsaw University of Life Sciences SGGW, Warsaw, Poland.
Independent Department, Laboratory of Molecular Imaging, Medical University of Białystok, Białystok, Poland.



Lyme neuroborreliosis (LNB) is a disease caused by spirochete Borrelia burgdorferi, involving the nervous system. It usually manifests as lymphocytic meningoradiculitis, but in rare cases, it can also lead to cerebrovascular complications. We aimed to perform a systematic review of all reported cases of LNB complicated by central nervous system vasculitis and stroke or transient ischemic attack (TIA).


We conducted a systematic review of literature between May 1987 and December 2016 with patients who presented with cerebrovascular course of LNB.


This study included 88 patients with a median age of 46 years. The median interval from onset of symptoms suggesting Lyme disease to first symptoms of cerebrovascular manifestations of LNB was 3.5 months. The most common cerebrovascular manifestation of LNB was ischemic stroke (76.1%), followed by TIA (11.4%). The posterior circulation was affected alone in 37.8% of patients, the anterior circulation in 24.4% of patients, and in 37.8% of cases, posterior and anterior circulations were affected simultaneously. The most common affected vessels were middle cerebral artery-in 19 cases, basilar artery-in 17 cases, and anterior cerebral artery-in 16 cases. A good response to antibiotic treatment was achieved in the vast number of patients (75.3%). The overall mortality rate was 4.7%.


Cerebral vasculitis and stroke due to LNB should be considered, especially in patients who live in or have come from areas with high prevalence of tick-borne diseases, as well as in those without cardiovascular risk factors, but with stroke-like symptoms of unknown cause.


Borrelia burgdorferi; Lyme neuroborreliosis; cerebrovascular manifestations; stroke; vasculitis; vasculopathy

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