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Thromb Haemost. 1988 Jun 16;59(3):349-52.

Bleeding symptoms in carriers of hemophilia A and B.

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  • 1Van Creveld Clinic, Bilthoven, The Netherlands.


In order to investigate the bleeding tendency in clinically identified carriers of hemophilia, a self-administered questionnaire was held among 135 carriers of hemophilia A and B, 25 females with relatives with hemophilia and a matched group consisting of 60 females without relatives with hemophilia. Carriers of hemophilia appeared to suffer more often from bleeding than their relatives or the matched unrelated control group. A relation was seen between factor VIII:C or IX:C activity and the tendency to bleed. Obligatory carriers with normal factor VIII:C levels showed no bleeding tendency and were in this respect similar to a group of 25 females with relatives with hemophilia. This study shows that it is important to assay factor VIII:C or IX:C also in those women in whom the carrier status has already been established otherwise.

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