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Exp Toxicol Pathol. 2017 Sep 5;69(7):461-468. doi: 10.1016/j.etp.2017.04.007. Epub 2017 May 2.

Reproductive toxicity of Roundup herbicide exposure in male albino rat.

Author information

1
Department of Zoology, Faculty of Science, Olabisi Onabanjo University Ago- Iwoye, Ogun State, Nigeria. Electronic address: fobillion@yahoo.com.
2
Department of Pure and Applied Zoology, College of Bioscience, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria.
3
Department of Environmental Management and Toxicology, College of Environmental Management, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria.
4
Department of Plant Science, Faculty of Science, Olabisi Onabanjo University Ago- Iwoye, Ogun State, Nigeria.

Abstract

The incidence of infertility in human is on the increase and the use of Roundup herbicide and presence of its residues in foodstuff is a major concern. This study therefore aim to assess the effect of Roundup on the reproductive capacity of 32 adult male albino rats randomized into 4 groups of 8 rats per group orally exposed to Roundup at 3.6mg/kg body weight(bw), 50.4mg/kgbw and 248.4mg/kgbw of glyphosate concentrations for 12 weeks while the control group was given distilled water. Serum level of reproductive hormone (testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin), oxidative stress indices in the testicular tissue, epididymal sperm morphology assessment and testicular histopathology of the rats were used as a diagnostic marker of reproductive dysfunction. Significant (p<0.05) alterations in the level of all the reproductive hormones and oxidative stress markers assayed were observed in rats exposed to Roundup. Significant reductions (p<0.05) in sperm count, percentage motility and significant (p<0.05) increased in abnormal sperm cells were observed in the exposed rats. Histopathologically, severe degenerative testicular architectural lesions were seen in the Roundup exposed rats. Roundup may interfere with spermatogenesis and impair fertility in male gonad.

KEYWORDS:

Agriculture; Food poison; Herbicide; Reproduction; Roundup

PMID:
28473188
DOI:
10.1016/j.etp.2017.04.007
[Indexed for MEDLINE]

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