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Endoscopy. 2017 Jul;49(7):634-642. doi: 10.1055/s-0043-105485. Epub 2017 May 4.

Gastroesophageal reflux after peroral endoscopic myotomy: a multicenter case-control study.

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Division of Gastroenterology and Hepatology, Johns Hopkins Hospital, Baltimore, Maryland, United States.
Digestive Endoscopy Unit, Catholic University, Gemelli University Hospital, Rome, Italy.
Department of Surgical Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
Gastroenterologie, Pavillon H Hôpital Edouard Herriot, Lyon, France.
Division of General and Gastrointestinal Surgery, The Ohio State University Wexner Medical Center, Columbus, Ohio, United States.
Department of Gastroenterology, CHA Bundang Medical Center, Seongnam, Korea.
Gastroenterology, King's College Hospital, London, United Kingdom.
Gastroenterologie, University of Lyon, Lyon, France.
Gastroenterology and Hepatology, Baylor College of Medicine, Houston, Texas, United States.
Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, United States.
IHU-USIAS, University of Strasbourg, France.


Background and study aims The variables associated with gastroesophageal reflux (GER) after peroral endoscopic myotomy (POEM) are largely unknown. This study aimed to: 1) identify the prevalence of reflux esophagitis and asymptomatic GER in patients who underwent POEM, and 2) evaluate patient and intraprocedural variables associated with post-POEM GER. Patients and methods All patients who underwent POEM and subsequent objective testing for GER (pH study with or without upper gastrointestinal [GI] endoscopy) at seven tertiary academic centers (one Asian, two US, four European) were included. Patients were divided into two groups: 1) DeMeester score ≥ 14.72 (cases) and 2) DeMeester score of < 14.72 (controls). Asymptomatic GER was defined as a patient with a DeMeester score ≥ 14.72 who was not consuming proton pump inhibitor (PPI). Results A total of 282 patients (female 48.2 %, Caucasian 84.8 %; mean body mass index 24.1 kg/m2) were included. Clinical success was achieved in 94.3 % of patients. GER evaluation was completed after a median follow-up of 12 months (interquartile range 10 - 24 months). A DeMeester score of ≥ 14.72 was seen in 57.8 % of patients. Multivariable analysis revealed female sex to be the only independent association (odds ratio 1.69, 95 % confidence interval 1.04 - 2.74) with post-POEM GER. No intraprocedural variables were associated with GER. Upper GI endoscopy was available in 233 patients, 54 (23.2 %) of whom were noted to have reflux esophagitis (majority Los Angeles Grade A or B). GER was asymptomatic in 60.1 %. Conclusion Post-POEM GER was seen in the majority of patients. No intraprocedural variables were identified to allow for potential alteration in procedural technique.

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