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Dermatology. 2017;233(2-3):141-144. doi: 10.1159/000471799. Epub 2017 May 5.

Spironolactone for the Treatment of Acne: A 4-Year Retrospective Study.

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Department of Dermatology, University of Cincinnati, Cincinnati, OH, USA.


Prior studies have demonstrated that spironolactone is an effective second-line treatment option for postadolescent acne, but has notable side effects. Data are, however, limited. We therefore present a 4-year retrospective study evaluating 291.5 patient-years of spironolactone for the treatment of acne. Our results showed that 86% of patients improved on spironolactone therapy. Further, patients who improved showed minimal side effects, supporting recent evidence that spironolactone is a safe option for acne treatment with a low risk of short-term adverse effects such as hyperkalemia. It is suggested that our study encourages consideration of spironolactone for postadolescent acne.


Acne; Female; Postadolescent acne

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