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Endocr Rev. 2017 Jun 1;38(3):255-266. doi: 10.1210/er.2017-00064.

Energy Metabolism of the Osteoblast: Implications for Osteoporosis.

Author information

1
Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, Missouri 63110.
2
Maine Medical Center Research Institute, Scarborough, Maine 04074.
3
Departments of Medicine and Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110.

Abstract

Osteoblasts, the bone-forming cells of the remodeling unit, are essential for growth and maintenance of the skeleton. Clinical disorders of substrate availability (e.g., diabetes mellitus, anorexia nervosa, and aging) cause osteoblast dysfunction, ultimately leading to skeletal fragility and osteoporotic fractures. Conversely, anabolic treatments for osteoporosis enhance the work of the osteoblast by altering osteoblast metabolism. Emerging evidence supports glycolysis as the major metabolic pathway to meet ATP demand during osteoblast differentiation. Glut1 and Glut3 are the principal transporters of glucose in osteoblasts, although Glut4 has also been implicated. Wnt signaling induces osteoblast differentiation and activates glycolysis through mammalian target of rapamycin, whereas parathyroid hormone stimulates glycolysis through induction of insulin-like growth factor-I. Glutamine is an alternate fuel source for osteogenesis via the tricarboxylic acid cycle, and fatty acids can be metabolized to generate ATP via oxidative phosphorylation although temporal specificity has not been established. More studies with new model systems are needed to fully understand how the osteoblast utilizes fuel substrates in health and disease and how that impacts metabolic bone diseases.

PMID:
28472361
PMCID:
PMC5460680
DOI:
10.1210/er.2017-00064
[Indexed for MEDLINE]
Free PMC Article

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