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Endocrinology. 2017 Jul 1;158(7):2052-2057. doi: 10.1210/en.2017-00250.

Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature.

Author information

1
Institut de Génomique Fonctionnelle de Lyon, INRA USC 1370, Université de Lyon, Université Lyon 1, CNRS UMR 5242, Ecole Normale Supérieure de Lyon, 69364 Lyon cedex 07, France.
2
Gene Regulation Section, Laboratory of Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-6264.
3
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215.
4
Division of Laboratory Research, Department of Endocrinology and Metabolic Diseases, University of Duisburg-Essen, 45127 Essen, Germany.
5
Department of Medicine, Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey 08903.
6
Laboratory of Hormonal Regulation, Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, 169857, Singapore.
7
Department of Medicine, University of Chicago, Chicago, Illinois 60637.
8
Department of Pediatrics, University of Chicago, Chicago, Illinois 60637.
9
Department of Genetics, University of Chicago, Chicago, Illinois 60637.

Abstract

Current literature makes a distinction between two pathways for thyroid hormone signaling: genomic and nongenomic. However, this classification is a source of confusion. We propose a clarification in the nomenclature that may help to avoid unproductive controversies and favor progress in this field of research. Four types of thyroid hormone signaling are defined, and the experimental criteria for classification are discussed.

PMID:
28472304
PMCID:
PMC6283428
DOI:
10.1210/en.2017-00250
[Indexed for MEDLINE]
Free PMC Article

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