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PLoS One. 2017 May 4;12(5):e0176335. doi: 10.1371/journal.pone.0176335. eCollection 2017.

dbOTU3: A new implementation of distribution-based OTU calling.

Author information

1
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America.
2
Center for Microbiome Informatics and Therapeutics, Institute for Medical Engineering and Science, Cambridge, Massachusetts, United States of America.

Abstract

Distribution-based operational taxonomic unit-calling (dbOTU) improves on other approaches by incorporating information about the input sequences' distribution across samples. Previous implementations of dbOTU presented challenges for users. Here we introduce and evaluate a new implementation of dbOTU that is faster and more user-friendly. We show that this new implementation has theoretical and practical improvements over previous implementations of dbOTU, making the algorithm more accessible to microbial ecology and biomedical researchers.

PMID:
28472072
PMCID:
PMC5417438
DOI:
10.1371/journal.pone.0176335
[Indexed for MEDLINE]
Free PMC Article

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