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J Microsc. 2017 Sep;267(3):253-264. doi: 10.1111/jmi.12573. Epub 2017 May 4.

Noninvasive imaging systems for gametes and embryo selection in IVF programs: a review.

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Research and Clinical Center for Infertility, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.


Optimizing the efficiency of the in vitro fertilization procedure by improving pregnancy rates and reducing the risks of multiple pregnancies simultaneously are the primary goals of the current assisted reproductive technology program. With the move to single embryo transfers, the need for more cost-effective and noninvasive methods for embryo selection prior to transfer is paramount. These aims require advancement in a more acquire gametes/embryo testing and selection procedures using high-tech devices. Therefore, the aim of the present review is to evaluate the efficacy of noninvasive imaging systems in the current literatures, focusing on the potential clinical application in infertile patients undergoing assisted reproductive technology treatments. In this regards, three advanced imaging systems of motile sperm organelle morphology examination, polarization microscopy and time-lapse monitoring for the best selection of the gametes and preimplantation embryos are introduced in full.


Embryo selection; IMSI; MSOME; meiotic spindle; polarization microscope; time-lapse monitoring; zona pellucida birefringence

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