Format

Send to

Choose Destination
Z Rheumatol. 2017 Aug;76(6):539-546. doi: 10.1007/s00393-017-0308-2.

[Fifteen years of the histopathological synovitis score : Review and further developments of a diagnostic score].

[Article in German]

Author information

1
MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Max-Planck-Str. 5, 54296, Trier, Deutschland. krenn@patho-trier.de.
2
Department of Pathology and Laboratory Medicine, Hospital for Special Surgery, New York, USA.
3
Klinik und Poliklinik für Orthopädie, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.
4
MVZ-Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Max-Planck-Str. 5, 54296, Trier, Deutschland.
5
Pathologisch-bakteriologisches Institut, Otto Wagner Spital, Wien, Österreich.
6
Hôpital Orthopédique, Lausanne, Schweiz.
7
Rhumatologie, Centre hospital-universitaire de Nantes, Nantes, Frankreich.
8
TWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung GmbH, Hannover, Deutschland.
9
AKH-Wien, Universitätsklinik für Orthopädie, Medizinische Universität Wien, Wien, Österreich.
10
Med. Klinik, Rheumatologie und Klinische Immunologie, Charité, Berlin, Deutschland.
11
VMscope-Berlin, Berlin, Deutschland.
12
Paracelsus-Kliniken Deutschland, Osnabrück, Deutschland.
13
Orthopädische Universitätsklinik Erlangen, Erlangen, Deutschland.
14
Vreden Russian Scientific Research Institute of Traumatology and Orthopedics, Saint Petersburg, Russland.
15
Klinikum Ernst von Bergmann gemeinnützige GmbH, Potsdam, Deutschland.

Abstract

The histopathological synovitis score evaluates in a graded approach, as is largely usual for diagnostic histopathological scores, the immunological and inflammatory changes caused by synovitis. A synovitis score of between 1 and ≤ 4 is classified as low-grade (osteoarthritis-related synovitis, post-traumatic synovitis, meniscopathy-related synovitis and synovitis in hemochromatosis). Synovitis scores of between ≥ 5 and 9 are classified as high-grade synovitis (rheumatoid arthritis, psoriatic arthritis, Lyme's arthritis, post-infection/reactive arthritis and peripheral arthritis in Bechterew disease); sensitivity is 61.7% and sensitivity 96.1%. According to receiver operating characteristic (ROC) analysis (AUC: 0.8-0.9), diagnostic value is good. National and international acceptance of the synovitis score has grown since the first publication in 2002 and a related follow-up publication in 2006. PubMed data analysis (as of 11.01.2017) yielded the following citation values according to "cited by PubMed Central articles" for two publications relating to the synovitis score: there were 29 cited-by-PubMed articles for DOI: 10.1078/0344-0338-5710261 , and 44 cited-in-PubMed articles for the second publication, DOI: 10.1111/j.1365-2559.2006.02508 . This makes a total of 73 PubMed citations over a period of 15 years, thereby evidencing the score's international acceptance. Immunohistochemical determination of a number of CD antigens relevant to inflammation has been proposed to further specify the synovitis score for the purposes of risk stratification of high-grade synovitis (e.g., risk of progression and sensitivity to biological agents).

KEYWORDS:

Immunohistochemistry; Osteoarthritis; Rheumatoid arthritis; Synovial tissue; Synovitis

PMID:
28470440
DOI:
10.1007/s00393-017-0308-2

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center