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Org Biomol Chem. 2017 May 23;15(20):4308-4313. doi: 10.1039/c7ob00789b.

Synthesis of cyclooxygenase metabolites of 8,9-epoxyeicosatrienoic acid (EET): 11- and 15-hydroxy 8,9-EETs.

Author information

1
Departments of Entomology and Nematology and UC Davis Comprehensive Cancer Center, University of California Davis, One Shields Avenue, Davis, California 95616, USA. bdhammock@ucdavis.edu.

Abstract

COX metabolites of 8,9-EET, previously observed as potent mitogenic lipid mediators, were synthesized for the first time by using two synthetic approaches. These synthetic materials allow for structural confirmation of COX metabolites of 8,9-EET and further study of their biological roles.

PMID:
28470279
PMCID:
PMC5527127
DOI:
10.1039/c7ob00789b
[Indexed for MEDLINE]
Free PMC Article

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