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Mol Biol Cell. 2017 May 1;28(9):1161-1164. doi: 10.1091/mbc.E16-11-0762.

The link between autophagy and secretion: a story of multitasking proteins.

Author information

1
Institute of Basic Medical Sciences, University of Oslo, 3072 Oslo, Norway.
2
Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN 38105.
3
Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA 92093 sferronovick@ucsd.edu.

Abstract

The secretory and autophagy pathways can be thought of as the biosynthetic (i.e., anabolic) and degradative (i.e., catabolic) branches of the endomembrane system. In analogy to anabolic and catabolic pathways in metabolism, there is mounting evidence that the secretory and autophagy pathways are intimately linked and that certain regulatory elements are shared between them. Here we highlight the parallels and points of intersection between these two evolutionarily highly conserved and fundamental endomembrane systems. The intersection of these pathways may play an important role in remodeling membranes during cellular stress.

PMID:
28468940
PMCID:
PMC5415012
DOI:
10.1091/mbc.E16-11-0762
[Indexed for MEDLINE]
Free PMC Article

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