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Nutrients. 2017 May 1;9(5). pii: E0447. doi: 10.3390/nu9050447.

The Impact of Exclusive Enteral Nutrition (EEN) on the Gut Microbiome in Crohn's Disease: A Review.

Author information

1
Division of Pediatric Gastroenterology and Nutrition, IWK Health Centre, Halifax, Nova Scotia B3K 6R8, Canada. Amber.Maclellan@dal.ca.
2
Division of Pediatric Gastroenterology and Nutrition, IWK Health Centre, Halifax, Nova Scotia B3K 6R8, Canada. Jessica.Connors@iwk.nshealth.ca.
3
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. Jessica.Connors@iwk.nshealth.ca.
4
Department of Applied Human Nutrition, Mount Saint Vincent University, Halifax, Nova Scotia, Canada. Shannan.Grant2@msvu.ca.
5
Division of Pediatric Gastroenterology and Nutrition, IWK Health Centre, Halifax, Nova Scotia B3K 6R8, Canada. Leah.Cahill@dal.ca.
6
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada. morgan.g.i.langille@dal.ca.
7
Division of Pediatric Gastroenterology and Nutrition, IWK Health Centre, Halifax, Nova Scotia B3K 6R8, Canada. johanvanlimbergen@dal.ca.
8
Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada. johanvanlimbergen@dal.ca.
9
Department of Immunology & Microbiology, Dalhousie University, Halifax, Nova Scotia, Canada. johanvanlimbergen@dal.ca.

Abstract

Crohn's disease (CD), a form of inflammatory bowel disease (IBD), is thought to arise from a complex interaction of genetics, the gut microbiome, and environmental factors, such as diet. There is clear evidence that dietary intervention is successful in the treatment of CD-exclusive enteral nutrition (EEN) is able to induce remission in up to 80% of CD patients. While the mechanism of action of EEN is not clear, EEN is known to cause profound changes in the gut microbiome. Understanding how EEN modifies the gut microbiome to induce remission could provide insight into CD etiopathogenesis and aid the development of microbiome-targeted interventions to guide ongoing dietary therapy to sustain remission. This review includes current literature on changes in composition and function of the gut microbiome associated with EEN treatment in CD patients.

KEYWORDS:

Crohn’s disease; exclusive enteral nutrition; microbiome

PMID:
28468301
PMCID:
PMC5452177
DOI:
10.3390/nu9050447
[Indexed for MEDLINE]
Free PMC Article

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