Format

Send to

Choose Destination
Cell Metab. 2017 May 2;25(5):991-992. doi: 10.1016/j.cmet.2017.04.022.

Beyond Making Ends Meet: DNA-PK, Metabolism, and Aging.

Author information

1
Department of Biology, University of Rochester, Rochester, NY 14627, USA.
2
Department of Biology, University of Rochester, Rochester, NY 14627, USA. Electronic address: vera.gorbunova@rochester.edu.

Abstract

DNA-dependent protein kinase (DNA-PK), a central player in DNA double-strand break (DSB) repair, shows emerging roles in metabolic regulation. In this issue of Cell Metabolism, Park et al. (2017) elucidate a molecular mechanism whereby DNA-PK negatively regulates AMPK, contributing to metabolic and fitness decline during aging.

PMID:
28467943
DOI:
10.1016/j.cmet.2017.04.022
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center