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Cell Metab. 2017 May 2;25(5):1027-1036. doi: 10.1016/j.cmet.2017.04.015.

Metabolic Flexibility in Health and Disease.

Author information

1
Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Sanford Burnham Prebys Medical Discovery Institute, 301 East Princeton Street, Orlando, FL 32804, USA. Electronic address: bret.goodpaster@flhosp.org.
2
Translational Research Institute for Metabolism and Diabetes, Florida Hospital, Sanford Burnham Prebys Medical Discovery Institute, 301 East Princeton Street, Orlando, FL 32804, USA.

Abstract

Metabolic flexibility is the ability to respond or adapt to conditional changes in metabolic demand. This broad concept has been propagated to explain insulin resistance and mechanisms governing fuel selection between glucose and fatty acids, highlighting the metabolic inflexibility of obesity and type 2 diabetes. In parallel, contemporary exercise physiology research has helped to identify potential mechanisms underlying altered fuel metabolism in obesity and diabetes. Advances in "omics" technologies have further stimulated additional basic and clinical-translational research to further interrogate mechanisms for improved metabolic flexibility in skeletal muscle and adipose tissue with the goal of preventing and treating metabolic disease.

KEYWORDS:

adipose tissue; exercise; insulin resistance; metabolic flexibility; obesity; skeletal muscle; type 2 diabetes

PMID:
28467922
PMCID:
PMC5513193
DOI:
10.1016/j.cmet.2017.04.015
[Indexed for MEDLINE]
Free PMC Article

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