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Cortex. 2017 Jul;92:119-138. doi: 10.1016/j.cortex.2017.03.016. Epub 2017 Apr 8.

Resting-state functional reorganization in Parkinson's disease: An activation likelihood estimation meta-analysis.

Author information

1
Department of Neurology, University Hospital Cologne, Germany; Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany; Institute of Medical Sciences and Technology, Shahid Beheshti University, Tehran, Iran; Sleep Disorders Research Center, Kermanshah University of Medical Sciences (KUMS), Kermanshah, Iran. Electronic address: masoudtahmasian@gmail.com.
2
Institute of Clinical Neuroscience & Medical Psychology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Institute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany; Institute of Neuroscience and Medicine (INM-1, INM-7), Research Center Jülich, Jülich, Germany.
3
Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
4
Department of Neurology, University Hospital Cologne, Germany.
5
Medical Research Council Brain Network Dynamics Unit at the University of Oxford, Oxford, United Kingdom; Nuffield Department of Clinical Neurosciences, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
6
Department of Neurology, University Hospital Cologne, Germany; Department of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
7
Department of Physics, Florida International University, Miami, FL, USA.
8
Research Imaging Institute, University of Texas Health Science Center, San Antonio, TX, USA; South Texas Veterans Health Care System, San Antonio, TX, USA.
9
Sleep Disorders Research Center, Kermanshah University of Medical Sciences (KUMS), Kermanshah, Iran.
10
Institute of Medical Sciences and Technology, Shahid Beheshti University, Tehran, Iran; School of Cognitive Sciences, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
11
Department of Neurology, University Hospital Cologne, Germany; Department of Neurology, Phillips University Marburg, Germany.
12
Institute for Systems Neuroscience, Medical Faculty, Heinrich-Heine University Düsseldorf, Germany; Department of Psychiatry, Psychotherapy, and Psychosomatics, RWTH Aachen University, Aachen, Germany.

Abstract

Parkinson's disease (PD) is a common progressive neurodegenerative disorder. Studies using resting-state functional magnetic resonance imaging (fMRI) to investigate underlying pathophysiology of motor and non-motor symptoms in PD yielded largely inconsistent results. This quantitative neuroimaging meta-analysis aims to identify consistent abnormal intrinsic functional patterns in PD across studies. We used PubMed to retrieve suitable resting-state studies and stereotactic data were extracted from 28 individual between-group comparisons. Convergence across their findings was tested using the activation likelihood estimation (ALE) approach. We found convergent evidence for intrinsic functional disturbances in bilateral inferior parietal lobule (IPL) and the supramarginal gyrus in PD patients compared to healthy subjects. In follow-up task-based and task-independent functional connectivity (FC) analyses using two independent healthy subject data sets, we found that the regions showing convergent aberrations in PD formed an interconnected network mainly with the default mode network (DMN). Behavioral characterization of these regions using the BrainMap database suggested associated dysfunction of perception and executive processes. Taken together, our findings highlight the role of parietal cortex in the pathophysiology of PD.

KEYWORDS:

ALE meta-analysis; Default mode network; Inferior parietal lobule; Resting-state fMRI

PMID:
28467917
DOI:
10.1016/j.cortex.2017.03.016
[Indexed for MEDLINE]

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