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J Biochem Mol Toxicol. 2017 Sep;31(9). doi: 10.1002/jbt.21928. Epub 2017 May 3.

Investigation of the effect of naringenin on oxidative stress-related alterations in testis of hydrogen peroxide-administered rats.

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Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Necmettin Erbakan University, Konya, Turkey.
KONÜDAM Experimental Medicine Application and Research Center, Necmettin Erbakan University, Konya, Turkey.
Department of Chemistry, Faculty of Science and Art, Adiyaman University, Adiyaman, Turkey.
Department of Histology and Embryology, Faculty of Meram Medicine, Necmettin Erbakan University, Konya, Turkey.
Department of Food Engineering, Faculty of Engineering, Adiyaman University, Adiyaman, Turkey.
Department of Science Education, Faculty of Education, Adiyaman University, Adiyaman, Turkey.


Testis tissue is prone to oxidation because its plasma membrane contains many polyunsaturated fatty acids. Naringenin is a plant-derived natural flavonoid. We investigated the possible ameliorative role of naringenin on the hydrogen peroxide (H2 O2 )-induced testicular damage in Wistar rats. Animals received 12 mg/kg H2 O2 by intraperitoneal injection, and 50 mg/kg naringenin via orogastric gavage for 4 weeks. In the H2 O2 group, the testis malondialdehyde level increased, while the amount of reduced glutathione, glutathione transferase activities, and the testis weight decreased. There were severe testicular damages in the H2 O2 group otherwise their grade were less in the naringenin + H2 O2 group. However, the serum testosterone concentrations decreased in both the H2 O2 and the naringenin + H2 O2 groups. The testicular zinc and calcium levels reduced in the H2 O2 -treated rats. In conclusion, the administration of H2 O2 caused oxidative stress in the testes and naringenin supplementation decreased the H2 O2 -induced effects, except for changes in testosterone levels.


hydrogen peroxide; naringenin; oxidative stress; testis; testosterone

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