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Nat Commun. 2017 May 3;8:15122. doi: 10.1038/ncomms15122.

Arabidopsis proteins with a transposon-related domain act in gene silencing.

Author information

1
Université Clermont Auvergne, CNRS, Inserm, GReD, Clermont-Ferrand F-63000, France.
2
Institute of Plant Science and Resources, Okayama University, 2-20-1 Chuo, Kurashiki 710-0046, Japan.
3
Department of Molecular Biology, Max Planck Institute for Developmental Biology, Tübingen D-72076, Germany.
4
Molekulare Pflanzenphysiologie, Biozentrum Klein Flottbek, Universität Hamburg, Hamburg D-22609, Germany.
5
Laboratoire Génome et Développement des Plantes (LGDP), CNRS, UMR5096, Université de Perpignan Via Domitia, 58 Avenue Paul Alduy, Perpignan Cedex 66860, France.

Abstract

Transposable elements (TEs) are prevalent in most eukaryotes, and host genomes have devised silencing strategies to rein in TE activity. One of these, transcriptional silencing, is generally associated with DNA methylation and short interfering RNAs. Here we show that the Arabidopsis genes MAIL1 and MAIN define an alternative silencing pathway independent of DNA methylation and short interfering RNAs. Mutants for MAIL1 or MAIN exhibit release of silencing and appear to show impaired condensation of pericentromeric heterochromatin. Phylogenetic analysis suggests not only that MAIL1 and MAIN encode a retrotransposon-related plant mobile domain, but also that host plant mobile domains were captured by DNA transposons during plant evolution. Our results reveal a role for Arabidopsis proteins with a transposon-related domain in gene silencing.

PMID:
28466841
PMCID:
PMC5418596
DOI:
10.1038/ncomms15122
[Indexed for MEDLINE]
Free PMC Article

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