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Pharm Res. 2017 Aug;34(8):1551-1555. doi: 10.1007/s11095-017-2163-x. Epub 2017 May 2.

Preemptive Panel-Based Pharmacogenetic Testing: The Time is Now.

Author information

1
Department of Pharmacotherapy and Translational Research, and Center for Pharmacogenomics, University of Florida College of Pharmacy, PO Box 100486, Gainesville, Florida, 32610-0486, USA. kweitzel@cop.ufl.edu.
2
UF Health Personalized Medicine Program,, Gainesville, Florida, USA. kweitzel@cop.ufl.edu.
3
Department of Pharmacotherapy and Translational Research, and Center for Pharmacogenomics, University of Florida College of Pharmacy, PO Box 100486, Gainesville, Florida, 32610-0486, USA.
4
UF Health Personalized Medicine Program,, Gainesville, Florida, USA.
5
Department of Pharmaceutics, University of Florida College of Pharmacy, Orlando, Florida, USA.

Abstract

While recent discoveries have paved the way for the use of genotype-guided prescribing in some clinical environments, significant debate persists among clinicians and researchers about the optimal approach to pharmacogenetic testing in clinical practice. One crucial factor in this debate surrounds the timing and methodology of genotyping, specifically whether genotyping should be performed reactively for targeted genes when a single drug is prescribed, or preemptively using a panel-based approach prior to drug prescribing. While early clinical models that employed a preemptive approach were largely developed in academic health centers through multidisciplinary efforts, increasing examples of pharmacogenetic testing are emerging in community-based and primary care practice environments. However, educational and practice-based resources for these clinicians remain largely nonexistent. As such, there is a need for the health care system to shift its focus from debating about preemptive genotyping to developing and disseminating needed resources to equip frontline clinicians for clinical implementation of pharmacogenetics. Providing tools and guidance to support these emerging models of care will be essential to support the thoughtful, evidence-based use of pharmacogenetic information in diverse clinical practice environments. Specifically, the creation of efficient and accurate point-of-care resources, practice-based tools, and clinical models is needed, along with identification and dissemination of sustainable avenues for pharmacogenetic test reimbursement.

KEYWORDS:

genomic medicine; implementation; pharmacogenetic; pharmacogenomic; preemptive

PMID:
28466392
PMCID:
PMC5518315
DOI:
10.1007/s11095-017-2163-x
[Indexed for MEDLINE]
Free PMC Article

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