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Brain Struct Funct. 2017 Nov;222(8):3807-3817. doi: 10.1007/s00429-017-1435-x. Epub 2017 May 2.

Dysfunctions in striatal microstructure can enhance perceptual decision making through deficits in predictive coding.

Author information

1
Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany. christian.beste@uniklinikum-dresden.de.
2
Experimental Neurobiology, National Institute of Mental Health, Klecany, Czech Republic. christian.beste@uniklinikum-dresden.de.
3
Cognitive Neurophysiology, Department of Child and Adolescent Psychiatry, Faculty of Medicine, TU Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
4
XDP Study Group, Philippine Children's Medical Center, Quezon City, Philippines.
5
Institute of Neurogenetics, University of Lübeck, Lübeck, Germany.
6
Faculty of Neurology and Psychiatry, University of Santo Tomas, Manila, Philippines.

Abstract

An important brain function is to predict upcoming events on the basis of extracted regularities of previous inputs. These predictive coding processes can disturb performance in concurrent perceptual decision-making and are known to depend on fronto-striatal circuits. However, it is unknown whether, and if so, to what extent striatal microstructural properties modulate these processes. We addressed this question in a human disease model of striosomal dysfunction, i.e. X-linked dystonia-parkinsonism (XDP), using high-density EEG recordings and source localization. The results show faster and more accurate perceptual decision-making performance during distraction in XDP patients compared to healthy controls. The electrophysiological data show that sensory memory and predictive coding processes reflected by the mismatch negativity related to lateral prefrontal brain regions were weakened in XDP patients and thus induced less cognitive conflict than in controls as reflected by the N2 event-related potential (ERP). Consequently, attentional shifting (P3a ERP) and reorientation processes (RON ERP) were less pronounced in the XDP group. Taken together, these results suggests that striosomal dysfunction is related to predictive coding deficits leading to a better performance in concomitant perceptual decision-making, probably because predictive coding does not interfere with perceptual decision-making processes. These effects may reflect striatal imbalances between the striosomes and the matrix compartment.

KEYWORDS:

Basal ganglia; EEG; Perceptual decision making; Predictive coding; Sensory memory; Striosomes; X-linked dystonia parkinsonism

PMID:
28466359
DOI:
10.1007/s00429-017-1435-x
[Indexed for MEDLINE]

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