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J Antimicrob Chemother. 1988 Aug;22(2):185-92.

Intraphagocytic penetration of antibiotics.

Author information

1
Laboratoire d'Investigation Clinique H. J. Tagnon, Service de M├ędecine, Institut Jules Bordet, Brussels, Belgium.

Abstract

The penetration of several antibiotics into human polymorphonuclear leucocytes was measured with a bioassay. The aminoglycosides (gentamicin, netilmicin), oxacillin and LY146032, a new lipopeptidic antibiotic, had a penetration which was generally less than 60%, whereas new fluoro-quinolones (enoxacin, ciprofloxacin, CI934, Ro236240) and rifamycins (rifampicin, LM427) were concentrated 2.4 to 14.2-fold. The concentration of vancomycin and teicoplanin associated with the neutrophils appeared to be saturable over the range of extracellular concentrations tested (5-20 mg/l). Coumermycin, an inhibitor of DNA-gyrase, was highly concentrated (11.3 to 16.6-fold) within the neutrophils. The penetration of clindamycin and erythromycin was low (0.60- to 1.48-fold).

PMID:
2846489
DOI:
10.1093/jac/22.2.185
[Indexed for MEDLINE]

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