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Head Neck. 2017 Jul;39(7):1412-1420. doi: 10.1002/hed.24781. Epub 2017 May 2.

Changing trends in the management of the neck in oropharyngeal squamous cell carcinoma.

Author information

1
Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 263, FI-00029 HUS, Helsinki, Finland.
2
Department of Oncology, University of Helsinki and Helsinki University Hospital, P.O. Box 180, FI-00029 HUS, Helsinki, Finland.
3
Department of Pathology, University of Helsinki, HUSLAB, and Helsinki University Hospital, P.O. Box 21, FI-00014, Helsinki, Finland.
4
Research Programs Unit, Translational Cancer Biology, University of Helsinki, P.O. Box 63, FI-00014, Helsinki, Finland.
5
Department of Surgery, University of Helsinki and Helsinki University Hospital, University of Helsinki, P.O. Box 22, FI-00014, Helsinki, Finland.
6
Department of Pathology, University of Helsinki and Helsinki University Hospital, University of Helsinki, P.O. Box 21, FI-00014 Helsinki, Finland.

Abstract

BACKGROUND:

Treatment for oropharyngeal squamous cell carcinoma (SCC) has changed toward a more oncologic approach. We evaluated treatment of the neck, the incidence of regional recurrences, and factors associated with regional recurrence during the treatment approach transition period in patients with regional lymph node metastasis.

METHODS:

All patients with oropharyngeal SCC diagnosed at the Helsinki University Hospital during 2000-2009 were analyzed for clinicopathological factors, treatment, p16 expression, and regional recurrence.

RESULTS:

Altogether, 169 patients had a complete response, and among them regional recurrence occurred in 5 patients (4.7%) treated with surgery ± radiotherapy (RT) or chemoradiotherapy (CRT) and in 2 patients (3.2%) treated with RT or CRT ± surgery. All these 7 patients had N2b disease or higher, and 5 of them had regional recurrence in the contralateral side of the neck.

CONCLUSION:

The incidence of regional recurrence was low, and remained unchanged despite the increased use of RT or CRT ± surgery. Treatment and follow-up of the contralateral neck warrants special attention in patients with advanced neck disease (≥N2b).

KEYWORDS:

carcinoma; head and neck cancer; oropharynx; p16; regional recurrence

PMID:
28464452
DOI:
10.1002/hed.24781
[Indexed for MEDLINE]

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