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Cancer. 2017 Jul 1;123(13):2404-2412. doi: 10.1002/cncr.30667. Epub 2017 May 2.

Cervical cancer: A global health crisis.

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Department of Radiation Oncology, Stritch School of Medicine, Loyola University, Chicago, Illinois.
Gynecological Cancer InterGroup, Kingston, Ontario, Canada.
Department of Obstetrics, Gynecology, and Reproductive Science, Icahn School of Medicine at Mount Sinai, New York, New York.
Gamma West Cancer Services, Ogden, Utah.
Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Department of Obstetrics and Gynecology, University of Manchester, Manchester, United Kingdom.
Division of Hematology and Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland.
Department of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah.


Cervical cancer is the fourth most common malignancy diagnosed in women worldwide. Nearly all cases of cervical cancer result from infection with the human papillomavirus, and the prevention of cervical cancer includes screening and vaccination. Primary treatment options for patients with cervical cancer may include surgery or a concurrent chemoradiotherapy regimen consisting of cisplatin-based chemotherapy with external beam radiotherapy and brachytherapy. Cervical cancer causes more than one quarter of a million deaths per year as a result of grossly deficient treatments in many developing countries. This warrants a concerted global effort to counter the shocking loss of life and suffering that largely goes unreported. This article provides a review of the biology, prevention, and treatment of cervical cancer, and discusses the global cervical cancer crisis and efforts to improve the prevention and treatment of the disease in underdeveloped countries. Cancer 2017;123:2404-12.


Cervix Cancer Research Network (CCRN); Gynecological Cancer InterGroup (GCIG); activism; brachytherapy; cervical cancer; chemotherapy; developing world; human papillomavirus (HPV); vaccination

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