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Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00454-17. doi: 10.1128/AAC.00454-17. Print 2017 Jul.

NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas.

Author information

1
Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
2
Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
3
Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
4
J. Craig Venter Institute, La Jolla, California, USA.
5
Department of Laboratory Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
6
Department of Infectious Diseases, Cleveland Clinic, Cleveland, Ohio, USA.
7
Medical Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA.
8
Division of Infectious Diseases, University of North Carolina, Chapel Hill, North Carolina, USA david_vanduin@med.unc.edu robert.bonomo@va.gov.
9
Medical Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, Ohio, USA david_vanduin@med.unc.edu robert.bonomo@va.gov.
10
Department of Biochemistry, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
11
Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.
12
Department of Proteomics and Bioinformatics, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA.

Abstract

Among Gram-negative bacteria, carbapenem-resistant infections pose a serious and life-threatening challenge. Here, the CRACKLE network reports a sentinel detection and characterization of a carbapenem-resistant Klebsiella pneumoniae ST147 isolate harboring blaNDM-5 and blaOXA-181 from a young man who underwent abdominal surgery in India. blaNDM-5 was located on an IncFII plasmid of ≈90 kb, whereas blaOXA-181 was chromosomally encoded. Resistome and genome analysis demonstrated multiple copies of the transposable element IS26 and a "hot-spot region" in the IncFII plasmid.

KEYWORDS:

Klebsiella pneumoniae; NDM-5; OXA-181

PMID:
28461314
PMCID:
PMC5487671
DOI:
10.1128/AAC.00454-17
[Indexed for MEDLINE]
Free PMC Article

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