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Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00170-17. doi: 10.1128/AAC.00170-17. Print 2017 Jul.

Phenotypic and Molecular Evaluation of Echinocandin Susceptibility of Candida glabrata, Candida bracarensis, and Candida nivariensis Strains Isolated during 30 Years in Argentina.

Author information

1
Departamento de Micología, Instituto Nacional de Enfermedades Infecciosas Dr. Carlos G. Malbrán, Buenos Aires, Argentina.
2
Laboratorio de Micología y Diagnóstico Molecular, Cátedra de Parasitología y Micología, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina.
3
Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Santa Fe, Argentina.
4
Laboratorio de Micología y Diagnóstico Molecular, Cátedra de Parasitología y Micología, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina ggarcia@unl.edu.ar.

Abstract

The echinocandin susceptibilities of 122 Candida glabrata complex strains (including 5 Candida nivariensis and 3 Candida bracarensis strains) were evaluated by microdilution and compared with the results from a molecular tool able to detect FKS mutations. No echinocandin resistance was detected. The PCR results coincide with the MIC data in 99.25% of the cases (1 C. glabrata strain was misidentified as resistant) but were 20 h faster. C. nivariensis FKS genes were sequenced and showed differences with C. glabrataFKS genes.

KEYWORDS:

Candida bracarensis; Candida glabrata species complex; Candida nivariensis; echinocandin resistance; hot spot

PMID:
28461313
PMCID:
PMC5487631
DOI:
10.1128/AAC.00170-17
[Indexed for MEDLINE]
Free PMC Article

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