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Eur Respir J. 2017 May 1;49(5). pii: 1602019. doi: 10.1183/13993003.02019-2016. Print 2017 May.

Breastfeeding, maternal asthma and wheezing in the first year of life: a longitudinal birth cohort study.

Author information

1
Dept of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada meghan.azad@umanitoba.ca.
2
Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.
3
Dept of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada.
4
Dept of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
5
Dept of Pediatrics and Physiology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
6
Dept of Medicine, McMaster University, Hamilton, ON, Canada.
7
Dept of Pediatrics, University of Alberta, Edmonton, AB, Canada.
8
Dept of Pediatrics, Child and Family Research Institute and BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada.
9
Canadian Healthy Infant Longitudinal Development Study (investigators listed in acknowledgements).

Abstract

The impact of breastfeeding on respiratory health is uncertain, particularly when the mother has asthma. We examined the association of breastfeeding and wheezing in the first year of life.We studied 2773 infants from the Canadian Healthy Infant Longitudinal Development (CHILD) birth cohort. Caregivers reported on infant feeding and wheezing episodes at 3, 6 and 12 months. Breastfeeding was classified as exclusive, partial (supplemented with formula or complementary foods) or none.Overall, 21% of mothers had asthma, 46% breastfed for at least 12 months and 21% of infants experienced wheezing. Among mothers with asthma, breastfeeding was inversely associated with infant wheezing, independent of maternal smoking, education and other risk factors (adjusted rate ratio (aRR) 0.52; 95% CI 0.35-0.77 for ≥12 versus <6 months breastfeeding). Compared with no breastfeeding at 6 months, wheezing was reduced by 62% with exclusive breastfeeding (aRR 0.38; 95% CI 0.20-0.71) and by 37% with partial breastfeeding supplemented with complementary foods (aRR 0.63; 95% CI 0.43-0.93); however, breastfeeding was not significantly protective when supplemented with formula (aRR 0.89; 95% CI 0.61-1.30). Associations were not significant in the absence of maternal asthma (p-value for interaction <0.01).Breastfeeding appears to confer protection against wheezing in a dose-dependent manner among infants born to mothers with asthma.

Comment in

PMID:
28461293
DOI:
10.1183/13993003.02019-2016
[Indexed for MEDLINE]
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