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Indian Heart J. 2017 Mar - Apr;69(2):151-159. doi: 10.1016/j.ihj.2016.09.008. Epub 2016 Sep 25.

Immunomodulatory and antioxidant effects of saffron aqueous extract (Crocus sativus L.) on streptozotocin-induced diabetes in rats.

Author information

1
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran. Electronic address: samarghandians@mums.ac.ir.
2
Department of Genetics, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
3
Department of Immunogenetics, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

INTRODUCTION:

Crocus sativus L. (saffron) has many biological effects such as antioxidant property. The present study investigated the immunomodulatory effects of the aqueous saffron extract on streptozotocin (STZ)-induced diabetic rats.

MATERIALS AND METHODS:

In this study, the rats were divided into the following groups of 9 animals each: control, untreated diabetic, three saffron extract-treated diabetic groups. Diabetes was induced by STZ in rats. Saffron was administered 3 days after STZ administration; these injections were continued to the end of the study (4 weeks). At the end of the 4-week period, blood was drawn for biochemical assays and the abdominal aorta was removed for detecting the inflammatory cytokines expression.

RESULTS:

We found that saffron decreased blood glucose, malondialdehyde, nitric oxide, total lipids, triglycerides, cholesterol levels significantly (p<0.01) and increased glutathione level, catalase, and superoxide dismutase activities in the saffron-treated diabetic groups compared with the untreated groups, in a dose dependent manner (p<0.05, p<0.01, p<0.001). On the other hand, saffron-treated diabetic rats inhibited the expression of inflammatory cytokines in the abdominal aorta versus the untreated diabetic rats.

CONCLUSION:

Our results validate the use of saffron as a treatment against diabetes mellitus and its vascular complications.

KEYWORDS:

Antioxidant; Aorta; Diabetes mellitus; Free radical; IL-6; Lipid profile; Oxidant; Saffron; TNF-α

PMID:
28460761
PMCID:
PMC5414951
DOI:
10.1016/j.ihj.2016.09.008
[Indexed for MEDLINE]
Free PMC Article

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