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Expert Opin Investig Drugs. 2017 Jun;26(6):735-739. doi: 10.1080/13543784.2017.1323868.

Why do trials for Alzheimer's disease drugs keep failing? A discontinued drug perspective for 2010-2015.

Author information

1
a Alzheimer's and Memory Disorders Division , Barrow Neurological Institute, St. Joseph's Hospital and Medical Center , Phoenix , Arizona , USA.

Abstract

There are dozens of drugs in development for AD with billions of dollars invested. Despite the massive investment in AD drugs and a burgeoning pipeline, there have been more setbacks and failures than treatment successes. Areas covered: The classes of drugs that have failed to date include the monoclonal antibodies, the gamma secretase inhibitors, dimebon, neurochemical enhancers, and one tau drug. Data for these compounds were sought through a PubMed search and a clinicaltrials.gov search. Expert opinion: The obvious question to be posed is: Why are they failing? Is the treatment of symptomatic dementia too late? Are the therapeutic targets incorrect? Are the clinical methodologies imprecise, misleading, or inaccurate? This review summarizes the drugs that have failed during 2010-2015 and offers possible theories as to why they have failed.

KEYWORDS:

Alzheimer’s; Amyloid; clinical trials; dimebon; monoclonal antibodies; secretase inhibitors

PMID:
28460541
PMCID:
PMC5576861
DOI:
10.1080/13543784.2017.1323868
[Indexed for MEDLINE]
Free PMC Article

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