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Biol Res Nurs. 2017 Jul;19(4):456-464. doi: 10.1177/1099800417707268. Epub 2017 May 1.

A Randomized Controlled Trial of the Effects of Mindfulness-Based Stress Reduction (MBSR[BC]) on Levels of Inflammatory Biomarkers Among Recovering Breast Cancer Survivors.

Author information

1
1 Moffitt Cancer Center and Research Institute, Tampa, FL, USA.
2
2 College of Nursing, University of South Florida, Tampa, FL, USA.
3
3 Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
4
4 Breast Health Clinical and Research Integrated Strategic Program, University of South Florida, Tampa, FL, USA.
5
5 National Cancer Institute, Bethesda, MD, USA.
6
6 College of Nursing, University of Florida, Gainesville, FL, USA.
7
7 Department of Internal Medicine, University of Virginia, Charlottesville, VA, USA.
8
8 Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, Tampa, FL, USA.

Abstract

PURPOSE:

The purpose of this substudy of a large randomized controlled trial was to evaluate the efficacy of the Mindfulness-Based Stress Reduction (Breast Cancer) (MBSR[BC]) program compared to usual care (UC) in normalizing blood levels of pro-inflammatory cytokines among breast cancer survivors (BCS).

METHOD:

A total of 322 BCS were randomized to either a 6-week MBSR(BC) program or a UC. At baseline and 6 and 12 weeks, 10 ml of venous blood and demographic and clinical data were collected and/or updated. Plasma cytokines (interleukin [IL]-1β, IL-6, IL-10, tumor necrosis factor [TNF] α, transforming growth factor [TGF] β1, soluble tumor necrosis factor receptor [sTNFR] 1) were assayed. Linear mixed models were used to assess cytokine levels across three time points (baseline and 6 and 12 weeks) by group (MBSR[BC] vs. UC).

RESULTS:

Of the six measured cytokines, three were nondetectable at rates greater than 50% (IL-10, IL-1β, TGF-β1) and, because of overall low prevalence, were not analyzed further. For the remaining cytokines (TNFα, IL-6, sTNFR1), results showed that TNFα and IL-6 increased during the follow-up period (between 6 and 12 weeks) rather than during the MBSR(BC) training period (between baseline and 6 weeks), while sTNFR1 levels did not change significantly across the 12-week period.

CONCLUSIONS:

Study results suggest that MBSR(BC) affects cytokine levels in BCS, mainly with increases in TNFα and IL-6. The data further suggest that B-cell modulation may be a part of immune recovery during breast cancer management and that increases in TNFα and IL-6 may be markers for MBSR(BC)-related recovery.

KEYWORDS:

MBSR(BC); Mindfulness-Based Stress Reduction; biomarkers; breast cancer; cytokines

PMID:
28460534
PMCID:
PMC5942506
DOI:
10.1177/1099800417707268
[Indexed for MEDLINE]
Free PMC Article

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