Send to

Choose Destination
See comment in PubMed Commons below
Appl Physiol Nutr Metab. 2017 May 1. doi: 10.1139/apnm-2017-0077. [Epub ahead of print]

Exercise improves femoral whole-bone and tissue-level biomechanical properties in hyperphagic OLETF rats.

Author information

University of Missouri - Columbia, Nutrition and Exercise Physiology , 204 Gwynn Hall , Columbia, Missouri, United States , 65211 ;
University of Missouri , 4409 W. Millbrook , Columbia, Missouri, United States , 65203 ;
University of Missouri , One Hospital Drive , CE405, DC 043.00 , Columbia, Missouri, United States , 65212 ;
University of Missouri , 15 Aldeah Ave , Columbia, Missouri, United States , 65211 ;


An often-overlooked comorbidity of type 2 diabetes (T2D) is increased fracture risk. Since traditional T2D therapies focus solely on glucose homeostasis, there is an increased need for effective treatment strategies that improve both metabolic and bone health. The current study evaluated if previously reported protective effects of exercise (EX) on cortical bone geometry and biomechanical properties are due to the prevention of obesity compared to obese Otsuka Long-Evans Tokushima Fatty (OLETF) rats or the unique skeletal effects of exercise. Four-week old, male OLETF rats were randomly assigned to one of three groups, each fed a standard rodent chow diet until 40 weeks of age: ad libitum fed sedentary (O-SED), ad libitum fed EX (O-EX), or a control group body-weight matched to the O-EX group by caloric restriction (O-CR). Ad libitum fed sedentary Long-Evans Tokushima Otsuka (L-SED) were used as a lean control. EX or CR prevented the excess body mass accumulation and elevated HbA1c observed in O-SED. Total body BMD was greater in O-EX than O-CR, but similar to L-SED and O-SED. O-EX and O-CR had lower osteocalcin and TRAP5b than O-SED and L-SED. EX or CR prevented the ~3-fold increase in CTx in O-SED vs L-SED. EX increased femoral cortical mass accumulation and expansion at the mid-diaphysis compared to O-CR. EX or CR significantly increased tissue-level stiffness and strength compared to O-SED and L-SED, but O-EX had greater whole-bone stiffness than all other groups. In summary, EX has distinct advantages over CR for improving bone biomechanical properties in hyperphagic OLETF rats.

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Atypon
    Loading ...
    Support Center