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Annu Rev Biochem. 2017 Jun 20;86:193-224. doi: 10.1146/annurev-biochem-061516-044908. Epub 2017 May 1.

Proteasomal and Autophagic Degradation Systems.

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Institute of Biochemistry II, School of Medicine, Goethe University, 60598 Frankfurt am Main, Germany; email:
Buchmann Institute for Molecular Life Sciences, Goethe University, 60438 Frankfurt am Main, Germany.


Autophagy and the ubiquitin-proteasome system are the two major quality control pathways responsible for cellular homeostasis. As such, they provide protection against age-associated changes and a plethora of human diseases. Ubiquitination is utilized as a degradation signal by both systems, albeit in different ways, to mark cargoes for proteasomal and lysosomal degradation. Both systems intersect and communicate at multiple points to coordinate their actions in proteostasis and organelle homeostasis. This review summarizes molecular details of how proteasome and autophagy pathways are functionally interconnected in cells and indicates common principles and nodes of communication that can be therapeutically exploited.


UPS; aggrephagy; autophagy; chaperone; mitophagy; organelle homeostasis; p62–Keap1–Nrf2; proteasome; proteostasis; ubiquitination; xenophagy

[Indexed for MEDLINE]

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