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J Clin Endocrinol Metab. 2017 Jul 1;102(7):2552-2559. doi: 10.1210/jc.2017-00289.

Large Reduction in Adiponectin During Pregnancy Is Associated With Large-for-Gestational-Age Newborns.

Author information

1
Research Institute of Internal Medicine, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway.
2
Department of Obstetrics, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway.
3
National Advisory Unit for Womens Health, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway.
4
Faculty of Medicine, University of Oslo, 0027 Oslo, Norway.
5
Section of Clinical Immunology and Infectious Diseases, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway.
6
K.G. Jebsen Inflammatory Research Center, University of Oslo, 0027 Oslo, Norway.
7
K. G. Jebsen Thrombosis Research and Expertise Center, University of Tromsø, 9037 Tromsø, Norway.
8
Section of Specialized Endocrinology, Department of Endocrinology, Oslo University Hospital, Rikshospitalet, 0027 Oslo, Norway.

Abstract

Context:

Fetuses exposed to an obese intrauterine environment are more likely to be born large-for-gestational age (LGA) and are at increased risk of obesity in childhood and cardiovascular disease and/or type 2 diabetes mellitus as adults, but which factors that influence the intrauterine environment is less clear.

Objective:

To investigate the association between circulating levels of leptin and adiponectin, measured multiple times during pregnancy, and birth weight and prevalence of LGA or small-for-gestational-age infants. The association between birth weight and messenger RNA (mRNA) expression of adiponectin receptors and genes involved in nutrient transport in the placenta was also investigated.

Design:

Population-based prospective cohort [substudy of the STORK study (STORe barn og Komplikasjoner, translated as Large Babies and Complications)] from 2001 to 2008.

Setting:

University hospital. Patients or other participants: 300 women.

Main Outcome Measures:

Oral glucose tolerance test was performed twice along with adiponectin and leptin levels measured four times during pregnancy.

Results:

Circulating adiponectin was lower in mothers who gave birth to LGA offspring or had fetuses with high intrauterine abdominal circumference late in pregnancy. Adiponectin decreased most from early to late pregnancy in mothers who gave birth to LGA offspring, and the decrease was an independent predictor of birth weight. Adiponectin receptor 2 and system A amino acid transporter mRNA expression in placentas was negatively correlated with birth weight and was lower in placentas from LGA infants.

Conclusions:

Our findings suggest that maternal adiponectin may be an important predictor of fetal growth and birth weight, independent of body mass index and insulin resistance.

PMID:
28460045
DOI:
10.1210/jc.2017-00289
[Indexed for MEDLINE]

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